An array of possibilities for the study of autoimmunity
Article Abstract:
Autoimmunity is caused by a complex interaction of multiple gene products, unlike immunodeficiency diseases where a single dominant genetic trait is often the main disease determined. The DNA microarray studies have led to important advances in the study of autoimmunity and their use is limited owing to the problem of physiologically important splice variants that exist in individual cell populations.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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Loss of integrin [[alpha].sub.v][[beta].sub.8] on dendritic cells causes autoimmunity and colitis in mice
Article Abstract:
The mechanism that regulate cytokine transforming growth factor-[beta] (TGF-[beta]) activation and function in the immune system are studied. Finding reveal that loss of the TGF-[beta]-activating integrin [[alpha].sub.v][[beta].sub.8] on leukocytes creates severe inflammatory bowel disease and age-related autoimmunity in mice.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination
Article Abstract:
The functions and the properties of the plant homeodomain (PHD) finger found in RAG2 V(D)J recombinase are described. The finger is widely used for the recognition of histone H3 trimethylated at lysine 4 (H2K4me3).
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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